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irritant in Illness & disability topic

From Longman Dictionary of Contemporary Englishirritantir‧ri‧tant /ˈɪrɪtənt/ noun [countable]  1 ANNOY formal something that keeps annoying you over a period of time Low-flying aircraft are a constant irritant in this area.2 MIHURT/CAUSE PAINa substance that can make a part of your body painful and sore a skin irritant
Examples from the Corpus
irritantMy fatigue and this added irritant started to push me into a depression.One of these involves using the hind leg to scratch an area of skin to which an irritant has been applied.In this plant was a milky substance which was a drastic purge and irritant.There are few worse irritants for eyes and hand cuts.