1 [uncountable and countable]
an act of leaving a place, especially at the start of a journey [≠ arrival]
I saw Simon shortly before his departure for Russia.
There was a delay in the departure of our plane.
Mozart's departure from Paris in September 1778
2 [uncountable and countable]
an act of leaving an organization or position
He refused to discuss his departure from the government.
a flight, train etc that leaves at a particular time:
There are several departures for New York every day.
a way of doing something that is different from the usual, traditional, or expected way
Their new designs represent a departure from their usual style.
radical/major/significant etc departure (=a big change)
This would be a radical departure from the subsidy system.