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of course
a) used to show that what you are saying is expected or already known and so not surprising : 
You can pay by cheque, assuming of course you have a valid cheque card.Of course there are exceptions to every rule.
You can pay by cheque, assuming of course you have a valid cheque card.Of course there are exceptions to every rule.b) also course informal spoken used to say yes or to give permission politely : 'Can I have a word with you?' 'Of course.' 'Can you give me a lift?' 'Course, no problem.'
'Can I have a word with you?' 'Of course.''Can you give me a lift?' 'Course, no problem.'c) also course spoken used to emphasize that what you are saying is true or correct : Of course he'll come!
Of course he'll come!2 used to say very strongly that something is not true or correct : He asked his father if it was true. ' Of course not,' Jack said. 'You don't mind if I call her?' 'No, course not.'
of course not
also course not spoken informalHe asked his father if it was true. ' Of course not,' Jack said.'You don't mind if I call her?' 'No, course not.'3
education
[countable]SECa) a series of lessons in a particular subject [= class American English]
b) British English a period of study in a particular subject, especially at university [= program American English]
! course is never followed by 'of': a course in English (NOT of English) ➔ correspondence course, crash course, refresher course, sandwich course taught course (=one which has formal lectures, rather than one in which a student studies alone)
4 a period of time or process during which something happens
time
[singular] during/in/throughout/over the course of something During the course of our conversation, it emerged that Bob had been in prison. Over the course of the next few years, the steel industry was reorganized.
During the course of our conversation, it emerged that Bob had been in prison.Over the course of the next few years, the steel industry was reorganized. in the course of doing something In the course of researching customer needs, we discovered how few families have adequate life insurance.
In the course of researching customer needs, we discovered how few families have adequate life insurance.5 the usual or natural way that something changes, develops, or is done
development
[singular] in the normal/natural/ordinary course of events In the normal course of events, a son would inherit from his father.
In the normal course of events, a son would inherit from his father. take/run its course (=develop in the usual way and reach a natural end) It seems the boom in World Music has run its course.
It seems the boom in World Music has run its course.6 the general plans someone has to achieve something or the general way something is happening :
plans
[singular, uncountable]7 an action or series of actions that you could take in order to deal with a particular situation :
actions
[countable usually singular]8 the planned direction taken by a boat or plane to reach a place :
direction
[countable usually singular, uncountable]TTWTTA10 one of the separate parts of a meal
meal
[countable]DF11 an area of land or water where races are held, or an area of land designed for playing golf : a particularly difficult course an 18-hole course ➔ assault course, obstacle course (1)
sport
[countable]DSa particularly difficult coursean 18-hole course12 an amount of medicine or medical treatment that you have regularly for a specific period of time
medical treatment
[countable] especially British English13 after some or enough time has passed [= eventually]: She'll get used to school in the course of time.
in (the) course of time
She'll get used to school in the course of time.14 the direction a river moves in : The course of the water was shown by a line of trees.
river
[countable]SGThe course of the water was shown by a line of trees.15 a layer of bricks, stone etc in a wall : a damp-proof course
wall
[countable]TBCa damp-proof course
