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dif‧fe‧rence S1 W1

1 [uncountable and countable] a way in which two or more people or things are not like each other [≠ similarity]COLLOCATIONS 
big/major/important/significant difference small/minor difference subtle difference (=not obvious) marked difference (=very noticeable) there's no difference (=they are the same) there's very little difference (=they are very similar) there's a world of difference (=they are very different) know/can tell the difference (=be able to recognize the difference) spot the difference (=notice the difference)
Class differences still play an important role in society.

big/major/important/significant difference small/minor difference subtle difference (=not obvious) marked difference (=very noticeable) there's no difference (=they are the same) there's very little difference (=they are very similar) there's a world of difference (=they are very different) know/can tell the difference (=be able to recognize the difference) spot the difference (=notice the difference)
Class differences still play an important role in society.2 [singular, uncountable] the amount by which one thing is greater or smaller than another
➔ split the difference
at split1 (9)3 to have an important effect or influence on something or someone :
Whatever she did, it made no difference.
make a/the difference
Whatever she did, it made no difference. make a/the difference between
It could make the difference between missing your train and getting to work on time.
It could make the difference between missing your train and getting to work on time.4 used to say that it does not matter to someone which thing happens, is chosen etc :
Morning or afternoon. It makes no difference to me.
it makes no difference to somebody
Morning or afternoon. It makes no difference to me.5 disagreements :
our/your/their differences
settle/resolve your differences (=agree not to argue any more)
6 a slight disagreement :
There have been some differences of opinion as to exactly how the money should be spent.
difference of opinion
There have been some differences of opinion as to exactly how the money should be spent.7 used to describe something which is interesting or unusual, especially in a good way :
an adventure holiday with a difference
with a difference
informal
an adventure holiday with a difference