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down-

1 at or towards the bottom or end of something [↪ up-]:
downstairs
downriver (=nearer to where it goes into the sea)
downstairs
downriver (=nearer to where it goes into the sea)2 used to show that something is being made smaller or less important [↪ up-]:
to downgrade a job (=make it less important)
to downsize a company (=reduce the number of jobs in it)
to downgrade a job (=make it less important)
to downsize a company (=reduce the number of jobs in it)3 used to show that something is bad or negative [↪ up-]:
the downside of a situation (=the negative part of it)
down-market products (=low quality products)
the downside of a situation (=the negative part of it)
down-market products (=low quality products)