Longman Dictionary of Contemporary English homepage

downer

 noun
     
Related topics: Drug Culture
down‧er informal
1 [countable]MDD a drug that makes you feel very relaxed or sleepy [↪ upper]
2 [singular] a person or situation that stops you feeling happy:
The weather was a bit of a downer.
3

be on a downer

British English to be sad or experiencing a series of sad events:
What's up with Ruth? She's been on a downer all week.
Definition from the Longman Dictionary of Contemporary English
Advanced Learner's Dictionary.

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