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ir‧re‧ver‧si‧ble
1 irreversible damage, change etc is so serious or so great that you cannot change something back to how it was before [≠ reversible] 
Fossil fuels have caused irreversible damage to the environment.
Fossil fuels have caused irreversible damage to the environment.2 if an illness or bad physical condition is irreversible, it will continue to exist and cannot be cured : Miller is in an irreversible coma. irreversible blindness
Miller is in an irreversible coma.irreversible blindness —irreversibly adverb: His reputation was irreversibly damaged by the affair.
His reputation was irreversibly damaged by the affair.