Longman Dictionary of Contemporary English homepage

irreversible

adjective
     
ir‧re‧ver‧si‧ble
1 irreversible damage, change etc is so serious or so great that you cannot change something back to how it was before [≠ reversible]
Fossil fuels have caused irreversible damage to the environment.
2 if an illness or bad physical condition is irreversible, it will continue to exist and cannot be cured:
Miller is in an irreversible coma.
irreversible blindness
irreversibly adverb:
His reputation was irreversibly damaged by the affair.

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