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loose2 [transitive] literary
1 to make something unpleasant begin : 
And now the anger Maggie had feared was loosed.
And now the anger Maggie had feared was loosed.2 to make something loose or to untie someone or something, especially an animal
3 to fire an arrow, a bullet from a gun etc
loose something on/upon somebody/something
phrasal verb literary to allow something dangerous or harmful to begin to affect a situation or other people : the evils loosed upon humanity in World War II
the evils loosed upon humanity in World War II