spokenused to emphasize that you are saying 'no' to something:
'Have you been reading my e-mail?' 'Of course not!'
'Do you mind if I bring a friend?' 'No, of course not.'
POLITENESS POLITENESS Use of course as a polite and friendly way of agreeing to something• 'Can I borrow your pen?'- 'Of course'. • Of course I'll help you. • 'Do you mind if I smoke?' - 'Of course not'.Do not use of course as a reply when someone asks you for information, because this can sound rude and unfriendly. If, for example, you asked someone • 'Is this the Swallow Hotel?' and they said • 'Of course it is' it would sound as though they thought the answer was obvious and that you were stupid to ask them.
Definition from the Longman Dictionary of Contemporary English Advanced Learner's Dictionary.
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