How to use
during the time that something is happening
They arrived while we were having dinner.
While she was asleep, thieves broke in and stole her handbag.
She met Andy while working on a production of Carmen.
see usage note
all the time that something is happening
Would you look after the children while I do the shopping?
used to emphasize the difference between two situations, activities etc
Schools in the north tend to be better equipped, while those in the south are relatively poor.
in spite of the fact that
While never a big eater, he did snack a lot.
While there was no conclusive evidence, most people thought he was guilty.
while I'm/you're etc at/about it
used to suggest that someone should do something at the same time that they do something else
Print out what you've written, and while you're at it make a copy for me.
Definition from the Longman Dictionary of Contemporary English
Advanced Learner's Dictionary.
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While shepherds watched their flocks by night
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